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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-07-16
摘要
Host-pathogen interactions impose recurrent selective pressures that lead to constant 適應 and counter-適應 in both competing 物種. Here, we sought to study this 演化ary arms-race and assessed the impact of the innate 免疫 system on viral 族群 多樣性 and 演化, using D. melanogaster as model host and its natural pathogen Drosophila C 病毒 (DCV). We first isogenized eight fly genotypes generating animals defective for RNAi, Imd and Toll innate 免疫 pathways and also pathogen sensing and gut renewal pathways. Wild-type or mutant flies were then orally infected and DCV was serially passaged ten times. Viral 族群 多樣性 was studied after each viral passage by high-throughput sequencing, and infection phenotypes were assessed at the beginning and at the end of the passaging scheme. We found that the absence of any of the
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