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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-07-23
摘要
Explaining the 湧現 and maintenance of intratumor heterogeneity is an important question in 癌症 biology. Tumor cells can generate considerable subclonal 多樣性, which influences tumor growth rate, treatment resistance, and metastasis, yet we know remarkably little about how cells from different subclones interact. Here, we confronted two murine mammary 癌症 cell lines to determine both the nature and mechanisms of subclonal cellular interactions in vitro. Surprisingly, we found that, compared to monoculture, growth of the "winner" was enhanced by the presence of the "loser" cell line, whereas growth of the latter was reduced. 數學 modeling and laboratory assays indicated that these interactions are mediated by the production of paracrine metabolites resulting in the winner subclone effectively "farm
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