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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-11-15
摘要
Single-cell RNA sequencing (scRNA-seq) offers the possibility to monitor both host andvpathogens transcriptomes at the cellular level. Here, public scRNA-seq datasets from Drosophila melanogaster midgut cells were used to compare the differences in replication strategy and cellular responses between two fly picorna-like 病毒es, Thika 病毒 (TV) and D. melanogaster Nora 病毒 (DMelNV). TV exhibited lower levels of viral RNA accumulation but infected a higher number of cells compared to DMelNV. In both cases, viral RNA accumulation varied according to cell subtype. The cellular heat shock response to TV and DMelNV infection was cell-subtype- and 病毒-specific. Disruption of bottleneck genes at later stages of infection in the systemic response, as well as of translation-related genes in the cellular r
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