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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-11-25
摘要
Rapid 細菌l growth depends on the speed at which ribosomes can translate mRNA into 蛋白質s. mRNAs that encode successive stretches of proline can cause ribosomes to stall, substantially reducing translation speed. Such stalling is especially detrimental for 物種 that must grow and divide rapidly. Here, we focus on di-prolyl motifs (XXPPX) and ask whether their prevalence varies with growth rate. To find out we conducted a broad survey of such motifs in >3000 細菌l 基因組s across 35 phyla. Indeed, fast-growing 物種 encode fewer motifs than slow-growing 物種, especially in highly expressed 蛋白質s. We also found many di-prolyl motifs within thermophiles, where prolines can help maintain proteome stability. Moreover, 細菌 with complex, multicellular lifecycles also encode many di-prolyl motifs. This is especially
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