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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-12-02
摘要
蛋白質-蛋白質 interaction (PPI) 網絡s represent complex intra-cellular 蛋白質 interactions, and the presence or absence of such interactions can lead to 生物 changes in an organism. Recent 網絡-based approaches have shown that a phenotype's PPI 網絡's 韌性 to environmental perturbations is related to its placement in the tree of life; though we still do not know how or why certain intra-cellular factors can bring about this 韌性. Here, we explore the influence of gene expression and 網絡 properties on PPI 網絡s' 韌性. We use publicly available data of PPIs for E. coli, S. cerevisiae, and H. sapiens, where we compute changes in 網絡 韌性 as new nodes (蛋白質s) are added to the 網絡s under three node addition mechanisms-random, degree-based, and gene-expression-based attachments. By calculating the 韌性 of the resulting 網絡s, we
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