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原文連結
論文資訊
- 類型：已發表論文
- 日期：2022-03-09
摘要
Biochemical specificity is critical in enzyme function, 演化, and engineering. Here we employ an established kinetic model to dissect the effects of reactant geometry and 擴散 on product formation speed and accuracy in the presence of cognate (correct) and near-cognate (incorrect) substrates. Using this steady-state model for spherical geometries, we find that, for distinct kinetic regimes, the speed and accuracy of the reactions are optimized on different regions of the geometric landscape. From this model we deduce that accuracy can be strongly dependent on reactant geometric properties even for chemically limited reactions. Notably, substrates with a specific geometry and reactivity can be discriminated by the enzyme with higher efficacy than others through purely diffusive effects. For sim
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