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原文連結
論文資訊
- 類型：已發表論文
- 日期：2022-05-16
摘要
Background: Commonly, sequence and structure elements are assumed to evolve congruently, such that homologous sequence positions correspond to homologous structural features. Assuming congruent 演化, alignments based on sequence and structure similarity can therefore optimize both similarities at the same time in a single alignment. To model incongruent 演化, where sequence and structural features diverge positionally, we recently introduced bi-alignments. This generalization of sequence and structure-based alignments is best understood as alignments of two distinct pairwise alignments of the same entities: one modeling sequence similarity, the other structural similarity. Results: Optimal bi-alignments with affine gap costs (or affine shift cost) for two constituent alignments can be computed
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