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原文連結
論文資訊
- 類型：已發表論文
- 日期：2022-11-09
摘要
網絡 control theory is increasingly used to profile the 大腦’s energy landscape via simulations of 神經 dynamics. This approach estimates the control energy required to simulate the activation of 大腦 circuits based on structural connectome measured using 擴散 magnetic resonance imaging, thereby quantifying those circuits’ energetic efficiency. The 生物 basis of control energy, however, remains unknown, hampering its further application. To fill this gap, investigating temporal lobe epilepsy as a lesion model, we show that patients require higher control energy to activate the limbic 網絡 than healthy volunteers, especially ipsilateral to the seizure focus. The energetic imbalance between ipsilateral and contralateral temporolimbic regions is tracked by asymmetric patterns of glucose 代謝 measured using p
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