摘要 The 演化 of diverse phenotypes both involves and is

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論文資訊

• 類型：已發表論文
• 日期：2023

摘要

The 演化 of diverse phenotypes both involves and is constrained by molecular interaction 網絡s. When these 網絡s influence patterns of expression, we refer to them as gene regulatory 網絡s (GRNs). Here, we develop a model of GRN 演化 analogous to work from quasi-物種 theory, which is itself essentially the 突變-selection balance model from classical 族群 遺傳s extended to multiple loci. With this GRN model, we prove that-across a broad spectrum of selection pressures-the dynamics converge to a stationary distribution over GRNs. Next, we show from first principles how the frequency of GRNs at equilibrium is related to the topology of the genotype 網絡, in particular, via a specific 網絡 centrality measure termed the eigenvector centrality. Finally, we determine the structural characteristics of GRNs that are fav

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