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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-02-21
摘要
Epi遺傳 regulatory mechanisms allow multicellular organisms to develop distinct specialized cell identities despite having the same total 基因組. Cell-fate choices are based on gene expression programs and environmental cues that cells experience during embryonic development, and are usually maintained throughout the life of the organism despite new environmental cues. The 演化arily conserved Polycomb group (PcG) 蛋白質s form Polycomb Repressive Complexes that help orchestrate these developmental choices. Post-development, these complexes actively maintain the resulting cell fate, even in the face of environmental perturbations. Given the crucial role of these polycomb mechanisms in providing phenotypic fidelity (i.e. maintenance of cell fate), we hypothesize that their dysregulation after developme
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