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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-03-02
摘要
Human 癌症s comprise an heterogeneous array of 疾病s with different progression patterns and responses to therapy. However, they all develop within a host context that constrains their natural history. Since it occurs across the 多樣性 of organisms, one can conjecture that there is order in the 癌症 multiverse. Is there a way to capture the broad range of tumor types within a space of the possible? Here we define the oncospace, a coordinate system that integrates the ecological, 演化ary and developmental components of 癌症 complexity. The spatial position of a tumor results from its departure from the healthy tissue along these three axes, and progression trajectories inform about the components driving malignancy across 癌症 subtypes. We postulate that the oncospace topology encodes new 資訊 regarding tum
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