聖塔非研究所

顯微鏡下的神經元活動在癲癇發作的宏觀尺度上共同驅動混亂和僵化的動態

2023-04-05 · 已發表論文 · 更新 2026/08/30 下午12:48

摘要 Neuronal activity propagates through the 網絡 during seizures, engaging 大腦 dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can …

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論文資訊

  • 類型:已發表論文
  • 日期:2023-04-05

摘要

Neuronal activity propagates through the 網絡 during seizures, engaging 大腦 dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can relate spatiotemporal activity at the microscale with global 網絡 properties. Interestingly, propagating avalanches in healthy 網絡s are indicative of critical dynamics, where the 網絡 is organized to a 相變, which optimizes certain 計算 properties. Some have hypothesized that the pathologic 大腦 dynamics of epileptic seizures are an emergent property of microscale neuronal 網絡s collectively driving the 大腦 away from 臨界性. Demonstrating this would provide a unifying mechanism linking microscale spatiotemporal activity with emergent 大腦 dysfunction during seizures. Here, we investigated the effect of drug-induced seizures

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