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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-06-01
摘要
Mistranslation-the erroneous incorporation of amino acids into nascent 蛋白質s-is a source of 蛋白質 variation that is orders of magnitude more frequent than DNA 突變. Like other sources of non遺傳 variation, it can affect adaptive 演化. We study the 演化ary consequences of mistranslation with experimental data on mistranslation rates applied to three empirical adaptive landscapes. We find that mistranslation generally flattens adaptive landscapes by reducing the fitness of high fitness genotypes and increasing that of low fitness genotypes, but it does not affect all genotypes equally. Most importantly, it increases 遺傳 variation available to selection by rendering many neutral DNA 突變s nonneutral. Mistranslation also renders some beneficial 突變s deleterious and vice versa. It increases the probability of
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