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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-08-02
摘要
Newly formed endosomes mature into early endosomes by shedding one 蛋白質 and acquiring another. Here, the authors describe a trigger-and-convert mechanism driven by endosomal collisions and fusions that govern timeliness in ensemble maturations. Endosomal maturation is critical for robust and timely cargo transport to specific cellular compartments. The most prominent model of early endosomal maturation involves a phosphoinositide-driven gain or loss of specific 蛋白質s on individual endosomes, emphasising an autonomous and 隨機 description. However, limitations in fast, volumetric imaging long hindered direct whole cell-level measurements of absolute numbers of maturation events. Here, we use lattice light-sheet imaging and bespoke automated analysis to track individual very early (APPL1-positiv
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