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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-11-23
摘要
適應度景觀 theory predicts that rugged landscapes with multiple peaks impair Darwinian 演化, but experimental evidence is limited. In this study, we used 基因組 editing to map the fitness of >260,000 genotypes of the key metabolic enzyme dihydrofolate reductase in the presence of the 抗生素 trimethoprim, which targets this enzyme. The resulting landscape is highly rugged and harbors 514 fitness peaks. However, its highest peaks are accessible to evolving 族群s via abundant fitness-increasing paths. Different peaks share large basins of attraction that render the outcome of adaptive 演化 highly contingent on chance events. Our work shows that ruggedness need not be an obstacle to Darwinian 演化 but can reduce its predictability. If true in general, the complexity of optimization problems on realistic landscap
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