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原文連結
論文資訊
- 類型：已發表論文
- 日期：2023-12-05
摘要
Interactions between 突變s (epistasis) can add substantial complexity to genotype-phenotype maps, hampering our ability to predict 演化. Yet, recent studies have shown that the fitness effect of a 突變 can often be predicted from the fitness of its 遺傳 background using simple, linear relationships. This phenomenon, termed global epistasis, has been leveraged to reconstruct 適應度景觀s and infer adaptive trajectories in a wide variety of contexts. However, little attention has been paid to how patterns of global epistasis may be affected by environmental variation, despite this variation frequently being a major driver of 演化. This is particularly relevant for the 演化 of drug resistance, where antimicrobial drugs may change the environment faced by pathogens and shape their adaptive trajectories in ways
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