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原文連結
論文資訊
- 類型：已發表論文
- 日期：2024-06-14
摘要
The relative and synergistic contributions of 遺傳s and environment to interindividual 免疫 response variation remain unclear, despite implications in 演化ary biology and medicine. Here we quantify interactive effects of genotype and environment on 免疫 traits by investigating C57BL/6, 129S1 and PWK/PhJ inbred mice, rewilded in an outdoor enclosure and infected with the parasite Trichuris muris. Whereas cellular composition was shaped by interactions between genotype and environment, cytokine response heterogeneity including IFN gamma concentrations was primarily driven by genotype with consequence on worm burden. In addition, we show that other traits, such as expression of CD44, were explained mostly by 遺傳s on T cells, whereas expression of CD44 on B cells was explained more by environment acros
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