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原文連結
論文資訊
- 類型：已發表論文
- 日期：2024-08-01
摘要
The co演化ary dynamics of lytic 病毒es and microbes with CRISPR-Cas immunity exhibit alternations between sustained host control of viral proliferation and major viral 流行病學cs in previous 計算 models. These alternating dynamics have yet to be observed in other host-pathogen systems. Here, we address the breakdown of control and transition to large outbreaks with a 隨機 eco-演化ary model. We establish the role of host density-dependent competition in punctuated 病毒-driven succession and associated 多樣性 trends that concentrate escape pathways during control phases. Using infection and escape 網絡s, we derive the viral 湧現 probability whose fluctuations of increasing size and frequency characterize the approach to large outbreaks. We explore alternation probabilities as a function of non-dimensional paramete
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