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原文連結
論文資訊
- 類型：已發表論文
- 日期：2024-09-27
摘要
Orsay 病毒 (OrV) is the only known natural 病毒 affecting Caenorhabditis elegans, with minimal impact on the animal's fitness due to its robust innate 免疫 response. This study aimed to understand the interactions between C. elegans and OrV by tracking the infection's progression during larval development. Four distinct stages of infection were identified on the basis of viral load, with a peak in capsid-encoding RNA2 coinciding with the first signs of viral egression. Transcriptomic analysis revealed temporal changes in gene expression and functions induced by the infection. A specific set of up-regulated genes remained active throughout the infection, and genes correlated and anticorrelated with 病毒 accumulation were identified. Responses to OrV mirrored reactions to other biotic stressors, dis
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