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原文連結
論文資訊
- 類型：已發表論文
- 日期：2024-10-29
摘要
Motivation: Defective viral 基因組s (DVGs) are variants of the wild-type (wt) 病毒 that lack the ability to complete autonomously an infectious cycle. However, in the presence of their parental (helper) wt 病毒, DVGs can interfere with the replication, encapsidation, and spread of functional 基因組s, acting as a significant selective force in viral 演化. DVGs also affect the host's 免疫 responses and are linked to chronic infections and milder symptoms. Thus, identifying and characterizing DVGs is crucial for understanding infection prognosis. Quantifying DVGs is challenging due to their inability to sustain themselves, which makes it difficult to distinguish them from the helper 病毒, especially using high-throughput RNA sequencing. An accurate quantification is essential for understanding their very dyn
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