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原文連結
論文資訊
- 類型：已發表論文
- 日期：2024-10-30
摘要
One of the primary challenges in metabolic psychiatry is that the disrupted 大腦 functions that underlie psychiatric conditions arise from a complex set of downstream and feedback processes that span multiple spatiotemporal scales. Importantly, the same circuit can have multiple points of failure, each of which results in a different type of dysregulation, and thus elicits distinct cascades downstream that produce divergent signs and symptoms. Here, we illustrate this challenge by examining how subtle differences in circuit perturbations can lead to divergent clinical outcomes. We also discuss how 計算 models can perform the spatially heterogeneous integration and bridge in vitro and in vivo paradigms. By leveraging recent methodological advances and tools, 計算 models can integrate relevant pro
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