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原文連結
論文資訊
- 類型：已發表論文
- 日期：2025-01-22
摘要
The 細菌l 蛋白質 quality control (PQC) 網絡 comprises a set of genes that promote proteostasis (proteome homeostasis) through proper 蛋白質 folding and function via chaperones, proteases, and 蛋白質 translational machinery. It participates in vital cellular processes and influences organismal development and 演化. In this review, we examine the mechanistic bases for how the 細菌l PQC 網絡 influences molecular 演化. We discuss the relevance of PQC components to contemporary issues in 演化ary biology including epistasis, evolvability, and the navigability of 蛋白質 space. We examine other areas where proteostasis affects aspects of 演化 and physiology, including host-parasite interactions. More generally, we demonstrate that the study of 細菌l systems can aid in broader efforts to understand the relationship between geno
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