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原文連結
論文資訊
- 類型：已發表論文
- 日期：2025-04-05
摘要
Orthology inference lies at the foundation of comparative genomics research. The correct identification of loci which descended from a common ancestral sequence is not only complicated by sequence divergence but also duplication and other 基因組 rearrangements. The conservation of gene order, i.e. synteny, is used in conjunction with sequence similarity as an additional factor for orthology determination. Current approaches, however, rely on 基因組 annotations and are therefore limited. Here we present an annotation-free approach and compare it to synteny analysis with annotations. We find that our approach works better in closely related 基因組s whereas there is a better performance with annotations for more distantly related 基因組s. Overall, the presented algorithm offers a useful alternative to an
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