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論文資訊
- 類型：已發表論文
- 日期：2025-05-16
摘要
Galleria mellonella has emerged as an important host for the study of fungal virulence, insect 免疫 responses, and the evaluation of antifungal 智能體s. In this study, we investigated the dynamics of fungal infections in G. mellonella using Cryptococcus neoformans, a human pathogenic fungus. Since the analysis of infection dynamics requires a fine temporal resolution of larval death, we employed a photographic time-lapse technique that allowed us to simultaneously measure death by proxy of larval melanization and absence of movement. Larval mortality occurred in two phases, early and late, which differed in their timing of melanization. Early phase deaths occurred with rapid whole-body onset of melanization, followed by sudden cessation of movement several hours later. Contrastingly, late phase
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