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原文連結
論文資訊
- 類型：已發表論文
- 日期：2025-08-07
摘要
Three ingredients create the strikingly variable 免疫 trajectories observed across human 族群s: (i) 遺傳 variation, (ii) individual-scale generation of additional 遺傳 多樣性 solely in lymphocytes, and (iii) collision of these processes with a changing environment through life, triggering plastic responses that can have lasting effects. We explore what generates or reduces 免疫 variation, integrating recent empirical advances with potential overarching 演化ary principles. We posit that the multiple components of the 免疫 system each present trade-offs (such as self-defense-self-harm, and investments in memory-retaining flexibility for future responses) that vary through life, and that variation in how 免疫 components balance these trade-offs increases homeostasis to external and internal threats. Disentangli
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