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原文連結
論文資訊
- 類型：已發表論文
- 日期：2025-12-20
摘要
Our ability to define the causes of aging could enable targeted interventions to extend healthspan. Classical 演化的 models based on individual age have provided critical insights into empirical trajectories of aging; however, gaps remain. We argue that technological advances in data capture, resolution, and scale present a rich opportunity to shed light on heterogeneity in patterns of aging. 計算的 and data analysis advances have produced expanded theoretical models that explicitly address details of the underlying biology, introducing variables and dynamics that go beyond 'age' itself. We argue that by incorporating richer biological detail to create more integrative predictive models, we can gain insight into expected future distributions of aging within 族群, and better understand the molecular and demographic context in which selection has given rise to variability in aging. We provide an overview of existing models that address heterogeneity, and outline future directions and applications that would advance this key area in aging and biomedical research.
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